Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 334

As individuals age and grow, their tendons and ligaments decrease their aerobic metabolic rates and shift their energy production to predominantly anaerobic methods. The ability to produce energy in conditions that lack oxygen allows our tendons and ligaments to maintain their strength throughout long periods of activity. However, due to the fact that anaerobic metabolism generates far less energy than aerobically, tendons and ligaments struggle with repair. Unfortunately, there is currently no standardized treatment method to aid the healing of tendons. These factors make MSC utilization an attractive method to aid in the repair of tendons and ligaments. There have been several preclinical trials that found positive results for the treatment of tendon and ligament injury in rat, rabbit, pig, and horse models.

Due to the positive findings in the preclinical models, there were in 2014 six active clinical trials analyzing the effect of utilizing MSCs in the regeneration of damaged ligaments and tendons. Trials are at this writing being conducted to assess the effect on rotator cuff tears, Achilles tendinopathy, and damage to ligaments and tendons caused by rheumatoid arthritis and osteoarthritis. Positive outcomes from these studies have the potential to be a breakthrough in tendon and ligament regeneration and treatment for adults.