Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 335

Due to the early positive results, there were over 13 clinical trials taking place (in 2014) to identify the most effective method for utilization of MSCs for cartilage, tendon, and ligament regeneration. These next studies will attempt to clarify the therapeutic potential. First, these studies will attempt to more clearly identify the most appropriate MSC source that will lead to the most effective treatment for cartilage, tendon, or ligament conditions. Once the source is identified, there may be challenges associated with extraction and purification of the MSCs. Next, studies will have to identify the appropriate scaffolding and growth and transcription factors needed for treatment that will lead to the highest effectiveness.

In addition, there is potential for unplanned negative outcomes such as cardiomyopathy, neoplasm, and other side effects of treatment. While gaining an understanding of the most effective method of cartilage, tendon, and ligament regeneration, safety of treatment will have to be studied in depth.

Krishna S. Vyas

Brad St. Martin

University of Kentucky College of Medicine

See Also: Cartilage, Tendons, and Ligaments: Current Research on Isolation or Production of Therapeutic Cells; Cartilage, Tendons, and Ligaments: Development and Regeneration Potential; Cartilage, Tendons, and Ligaments: Existing or Potential Regenerative Medicine Strategies; Cartilage, Tendons, and Ligaments: Major Pathologies.