Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 367

Another risk specific to iASC therapy is genetic mutation or contamination. A benefit of using pluripotent iASC is the dramatically reduced incidence of adverse immune reaction; however, using an adult patient’s own cells also increases the risk that the aged cells contain activated oncogenes or other naturally occurring deleterious mutations. As these cells proliferate, the mutations are carried into progeny cells and the newly formed tissues.

In addition to natural genetic changes, contamination by the lab or hosting environment (in the case of SCNT or animal hosts) can lead to genetic contamination. Animal proteins in culture or animal hosts can contain viruses, which may incorporate into the cells ultimately transplanted. It is estimated that up to 30 percent of polio vaccine given in the late 1950s was contaminated by simian virus 40, a theretofore unknown virus found in the monkey kidney used for culturing the vaccine and which has since been associated with human cancers. It is important to note that although it can be difficult to monitor for unknown pathogens and contaminants, the modern laboratory protocols surrounding both research and tissue culture for implantation is far more rigorous than it was then.