Читать книгу Biological Mechanisms of Tooth Movement - Группа авторов - Страница 69

VIP is another neuropeptide with immunosuppressive properties. VIP is one of a group of regulatory molecules termed macrophage‐deactivating factors that are believed to prevent the excessive production of proinflammatory cytokines. Since the mid‐1990s, VIP has been identified as an important immunomodulatory peptide, capable of regulating the production of both pro‐ and anti‐inflammatory mediators. Interestingly, VIP can also counteract the inflammatory effects of DAMPs, suggesting that neural–immunological regulatory pathways can operate in the regulation of force‐induced OTM (Chorny and Delgado, 2008).