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Microscopic

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The differential diagnosis of Candida esophagitis includes reflux esophagitis, drug injury, glycogenic acanthosis, ectopic sebaceous glands, and other infections.

The differential diagnosis of HSV esophagitis includes other etiologies of mucosal ulceration, including other infections, Crohn's disease, HIV‐associated ulceration, and drug injury. In some cases, the cytologic atypia induced in the squamous epithelium by the viral cytopathic effects of HSV may be difficult to distinguish from squamous dysplasia/carcinoma, as well as radiation esophagitis.

Gastrointestinal Pathology

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