Читать книгу Gastrointestinal Pathology - Группа авторов - Страница 65

Currently, the examination of esophageal mucosal biopsies by hematoxylin and eosin (H&E) stained sections, with clinical correlation, remains the most reliable diagnostic test for EOE. The diagnostic value of ancillary studies in distinguishing eosinophilic esophagitis from gastroesophageal reflux disease and other conditions remains unproven.

Immunohistochemical stains targeting eosinophil peroxidase, major basic protein, and eosinophil‐derived neurotoxin, have been reported to enhance detection of eosinophils compared to evaluation of H&E sections, but these stains are not widely used in routine clinical practice. A recent study suggested that the presence of intra‐squamous IgG4 deposits by immunohistochemistry may be a useful adjunctive marker for EOE.

Molecular analyses of esophageal tissues, such as gene expression analysis of chemokines such as eotaxin‐3 (CCL26), and transcriptome analysis show promise to improve diagnosis and clinical monitoring, and to guide patient‐specific therapy.