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Preface

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Since 2004 we have held annually in Kyoto, Japan, a medical conference on heme oxygenase (HO), titled the ‘HO Research Forum’. To date, more than 80 papers have been presented at these conferences, and our knowledge of HO and carbon monoxide, one of the by-products by HO, has been greatly expanded. Recently, evidence has accumulated suggesting that carbon monoxide plays an important role in many physiological and pathological conditions. Thus, in the last decade there has been an extraordinarily rapid growth in our knowledge of gaseous molecules such as molecular oxygen, nitric oxide, hydrogen sulfide and carbon monoxide. These gaseous molecules have been shown to play important roles in signal transduction in biological systems.

This book is an attempt to highlight some of the impressive recent advances in gas biology. It was initiated by Dr. Hideo Ueda, but sadly illness prevented him from completing the project. As the subject matter of this book is of importance for most basic and clinical researchers involved in gas biology, we decided to take it on. We were fortunate to receive excellent manuscripts from authors in the field, and readers will find they contain many new insights into leading-edge research on gas biology.

We would like to thank the many authors and colleagues who have contributed to the success of this publication. Special thanks also go to Dr. Tomohisa Takagi for his assistance. Finally, we thank Karger Publishers for their cooperation and encouragement throughout the publication process.

Toshikazu Yoshikawa

Yuji Naito

Gas Biology Research in Clinical Practice

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