Читать книгу Current Perspectives in Kidney Diseases - Группа авторов - Страница 23

Sepsis is a serious medical condition frequently associated with the development of multiple organ failure and AKI. The association of sepsis and the loss of renal function determine high incidence of mortality and progression toward CKD. These negative results are possibly due to the lack of human invasive studies (i.e., kidney biopsy) and reliable pathogenic models. However, in recent years, large animal studies and ex vivo human experiments have provided new insights into the pathogenesis of S-AKI. Furthermore, the application of new RRT biotechnologies has opened a new scenario with encouraging clinical data. Despite most of these technologies (i.e., RAD, SCD, polymyxin and CPFA) need to be tested in large phase-3 clinical trials. Some technologies displayed impressive changes in patient mortality (up to 50% for RAD) or were proven to be effective by methanalitic investigations.