Читать книгу Intracranial Gliomas Part II - Adjuvant Therapy - Группа авторов - Страница 57

For LGG, FRT to a total dose of 45–54 in 1.8 Gy per fraction is usually considered. At MD Anderson Cancer Center, proton therapy may be utilized and offers the advantage of minimizing the volume of brain receiving lower doses of radiation (Fig. 2). Typically, the surgical cavity and residual T2/FLAIR hyperintensity are treated with a 1 cm margin as a CTV with an appropriate setup margin.

Fig. 2. A 36-year-old physician underwent gross total resection of a WHO grade II astrocytoma with high-risk molecular features including intact 1p/19q status and aneuploidy. Postoperatively she received proton-based adjuvant radiation to a dose of 50.4 CGE in 28 fractions. Note that the contralateral brain is largely spared from any radiation above 5 CGE.