Читать книгу Uric Acid in Chronic Kidney Disease - Группа авторов - Страница 28

Most studies have suggested that uric acid may also play a role in in the progression of hypertension, cardiovascular disease, metabolic syndrome, and renal disease. Animal studies demonstrate that elevated uric acid level causes hypertension and endothelial dysfunction, arteriolopathy, and CKD and studies in human suggest an association of hyperuricemia with CKD, hypertension, and cardiovascular disease. It is clear that uric acid is an important participant in the development of kidney damage. In the general population, an elevation of uric acid is correlated with decreased renal function. Uric acid is also associated with renal dysfunction in hypertensive patients, as well as with microalbuminuria in type 2 diabetes. Although they are better understood, the mechanisms by which the uric acid is cause of kidney damage.