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2. Local Osteolytic Hypercalcemia from Osteoclastic Activity and Bone Resorption Surrounding the Tumor Tissue

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This is the second most common mechanism, accounting for about 20% of cases. Breast cancer and hematological neoplasms (myeloma, lymphoma, leukemia) are the most important. Patients with local osteolytic hypercalcemia are characterized by extensive bone metastases or marrow infiltration and the bone scintigraphic scan is generally widely positive.

Parathyroid Disorders

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