Читать книгу Human Milk: Composition, Clinical Benefits and Future Opportunities - Группа авторов - Страница 25

Many epidemiological studies link breastfeeding to CVD risk factors. In our large historic RCT of EHM versus CM exposure in preterm neonates, we found at the 16-year follow-up that the EHM group had favorably reduced the LDL:HDL cholesterol ratio, diastolic blood pressure, insulin resistance, and metabolic tendency to fatness (leptin resistance) [31–33]. Thus, early HM feeding in a strictly randomized trial reduced 4 key risk factors for CVD. The effect size was large; for instance, the impact of early HM feeding on later cholesterol alone would be expected in adults to reduce CVD by 25% and death by 13–14%. These data add weight to the causal nature of a protective role of breastfeeding for future obesity and CVD.