Читать книгу Vaccines for Older Adults: Current Practices and Future Opportunities - Группа авторов - Страница 45

The described changes in NK cell subpopulations and functions, either due to chronological aging or CMV infection or both, may be druggable and influenced to result in better functioning of the immune system and prolonged health span. These interventions may be directed to modulate the epigenetic changes, the surface molecules such as Tim-3 or HLA-E or the signaling pathways as well as the metabolic switch from OXPHOS to aerobic glycolysis. Together, they will result in better NK functioning to decrease age-related diseases and act as efficient senolytics [156]. The modulation of NK functions may be also explored to render the vaccine more efficient.