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Vaccines for Older Adults: Current Practices and Future Opportunities
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Interdisciplinary Topics in
Gerontology and Geriatrics
Vaccines for Older Adults: Current Practices and Future Opportunities
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Contents
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How Inflammation Blunts Innate Immunity in Aging
Abstract
Inflammation and Aging
Critical Functions of Innate Immunity
Neutrophils
Monocytes
Macrophages
Dendritic Cells
Inflammation and Innate Immunity
Influence of Tissue Milieu on Innate Immune Cell Function
Skin
Lung
Lymph Node
Adipose Tissue
Mechanisms of Dysfunction in Innate Immune Cells during Aging
Altered Transcription after Stimulation
Impaired Mer Signaling
Reduced RIG-I Signaling
Energy Balance and Inflammation Regulation
Immune Cell Energy Metabolism
Bioactive Lipids
Perspectives and Future Directions
Acknowledgements
Disclosure Statement
References
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Natural Killer Cells, Aging, and Vaccination
Abstract
Introduction
NK Cells
NK Cell Phenotype
NK Cell Functions
Collaboration/Interaction with Other Immune Cells
NK Cells and Aging
Vaccination in the Elderly
NK Cells, Aging, and Vaccination in the Old
Perspective
Conclusion
Acknowledgements
Disclosure Statement
References
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