Читать книгу Vaccines for Older Adults: Current Practices and Future Opportunities - Группа авторов - Страница 33

1Liang SY, Mackowiak PA: Infections in the elderly. Clin Geriatr Med 2007;23:441–456, viii.

2Haq K, McElhaney JE: Immunosenescence: influenza vaccination and the elderly. Curr Opin Immunol 2014;29:38–42.

3Shen-Orr SS, Furman D, Kidd BA, Hadad F, Lovelace P, Huang YW, Rosenberg-Hasson Y, Mackey S, Grisar FA, Pickman Y, Maecker HT, Chien YH, Dekker CL, Wu JC, Butte AJ, Davis MM: Defective signaling in the JAK-STAT pathway tracks with chronic Inflammation and cardiovascular risk in aging humans. Cell Syst 2016;3:374–384 e374.

4Marcos-Perez D, Sanchez-Flores M, Maseda A, Lorenzo-Lopez L, Millan-Calenti JC, Gostner JM, Fuchs D, Pasaro E, Laffon B, Valdiglesias V: Frailty in older adults is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations. Front Immunol 2018;9:1056.

5Tanaka T, Biancotto A, Moaddel R, Moore AZ, Gonzalez-Freire M, Aon MA, Candia J, Zhang P, Cheung F, Fantoni G, Consortium CHI, Semba RD, Ferrucci L: Plasma proteomic signature of age in healthy humans. Aging Cell 2018;17:e12799.

6Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G: Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908:244–254.

7Dalbeth N, Merriman TR, Stamp LK: Gout. Lancet 2016;388:2039–2052.

8Qian F, Guo X, Wang X, Yuan X, Chen S, Malawista SE, Bockenstedt LK, Allore HG, Montgomery RR: Reduced bioenergetics and Toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging (Albany NY) 2014;6:131–139.

9Butcher SK, Chahal H, Nayak L, Sinclair A, Henriquez NV, Sapey E, O’Mahony D, Lord JM: Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 2001;70:881–886.

10Braga PC, Sala MT, Dal Sasso M, Pecile A, Annoni G, Vergani C: Age-associated differences in neutrophil oxidative burst (chemiluminescence). Exp Gerontol 1998;33:477–484.

11Tortorella C, Piazzolla G, Spaccavento F, Vella F, Pace L, Antonaci S: Regulatory role of extracellular matrix proteins in neutrophil respiratory burst during aging. Mech Ageing Dev 2000;119:69–82.

12Rao KM: Age-related decline in ligand-induced actin polymerization in human leukocytes and platelets. J Gerontol 1986;41:561–566.

13Rao KM, Currie MS, Padmanabhan J, Cohen HJ: Age-related alterations in actin cytoskeleton and receptor expression in human leukocytes. J Gerontol 1992;47:B37–B44.

14Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, Insall RH, Stockley RA, Lord JM: Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 2014;123:239–248.

15Montgomery RR, Shaw AC: Paradoxical changes in innate immunity in aging: recent progress and new directions. J Leukoc Biol 2015;98:937–943.

16Jorch SK, Kubes P: An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med 2017;23:279–287.

17Schauer C, Janko C, Munoz LE, Zhao Y, Kienhofer D, Frey B, Lell M, Manger B, Rech J, Naschberger E, Holmdahl R, Krenn V, Harrer T, Jeremic I, Bilyy R, Schett G, Hoffmann M, Herrmann M: Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med 2014;20:511–517.

18Fadini GP, Menegazzo L, Rigato M, Scattolini V, Poncina N, Bruttocao A, Ciciliot S, Mammano F, Ciubotaru CD, Brocco E, Marescotti MC, Cappellari R, Arrigoni G, Millioni R, Vigili de Kreutzenberg S, Albiero M, Avogaro A: NETosis Delays Diabetic Wound Healing in Mice and Humans. Diabetes 2016;65:1061–1071.

19Xu F, Zhang C, Zou Z, Fan EKY, Chen L, Li Y, Billiar TR, Wilson MA, Shi X, Fan J: Aging-related Atg5 defect impairs neutrophil extracellular traps formation. Immunology 2017;151:417–432.

20Hazeldine J, Harris P, Chapple IL, Grant M, Greenwood H, Livesey A, Sapey E, Lord JM: Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell 2014;13:690–698.

21Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD: β-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares. Cell Rep 2017;18:2077–2087.

22Ziegler-Heitbrock L: Blood Monocytes and Their Subsets: Established Features and Open Questions. Front Immunol 2015;6:423.

23van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC: Age-associated defect in human TLR-1/2 function. J Immunol 2007;178:970–975.

24van Duin D, Allore HG, Mohanty S, Ginter S, Newman FK, Belshe RB, Medzhitov R, Shaw AC: Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis 2007;195:1590–1597.

25Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A: Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science 2016;352:463–466.

26Molony RD, Nguyen JT, Kong Y, Montgomery RR, Shaw AC, Iwasaki A: Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. Sci Signal 2017;10:eaan2392.

27Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR: Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2012;11:104–110.

28Gabanyi I, Muller PA, Feighery L, Oliveira TY, Costa-Pinto FA, Mucida D: Neuro-immune interactions drive tissue programming in intestinal macrophages. Cell 2016;164:378–391.

29Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Deep Dixit V: Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 2017;550:119–123.

30Pirzgalska RM, Seixas E, Seidman JS, Link VM, Sanchez NM, Mahu I, Mendes R, Gres V, Kubasova N, Morris I, Arus BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass CK, Domingos AI: Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine. Nat Med 2017;23:1309–1318.

31Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR: Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol 2008;82:7613–7623.

32Hoffman KW, Sachs D, Bardina SV, Michlmayr D, Rodriguez CA, Sum J, Foster GA, Krysztof D, Stramer SL, Lim JK: Differences in early cytokine production are associated with development of a greater number of symptoms following West Nile virus infection. J Infect Dis 2016;214:634–643.

33Yin L, Zheng D, Limmon GV, Leung NH, Xu S, Rajapakse JC, Yu H, Chow VT, Chen J: Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia. Respir Res 2014;15:116.

34Toapanta FR, Ross TM: Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res 2009;10:112.

35Zhao J, Zhao J, Legge K, Perlman S: Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest 2011;121:4921–4930.

36Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC: Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis. Aging Cell 2014;13:699–708.

37Granot T, Senda T, Carpenter DJ, Matsuoka N, Weiner J, Gordon CL, Miron M, Kumar BV, Griesemer A, Ho SH, Lerner H, Thome JJC, Connors T, Reizis B, Farber DL: Dendritic cells display subset and tissue-specific maturation dynamics over human life. Immunity 2017;46:504–515.

38Jing Y, Shaheen E, Drake RR, Chen N, Gravenstein S, Deng Y: Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood. Hum Immunol 2009;70:777–784.

39Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC: Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 2010;184:2518–2527.

40Qian F, Wang X, Zhang L, Lin A, Zhao H, Fikrig E, Montgomery RR: Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis 2011;203:1415–1424.

41Sridharan A, Esposo M, Kaushal K, Tay J, Osann K, Agrawal S, Gupta S, Agrawal A: Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. Age (Dordr) 2011;33:363–376.

42Canaday DH, Amponsah NA, Jones L, Tisch DJ, Hornick TR, Ramachandra L: Influenza-induced production of interferon-alpha is defective in geriatric individuals. J Clin Immunol 2010;30:373–383.

43Prakash S, Agrawal S, Cao JN, Gupta S, Agrawal A: Impaired secretion of interferons by dendritic cells from aged subjects to influenza: role of histone modifications. Age (Dordr) 2013;35:1785–1797.

44Stout-Delgado HW, Yang X, Walker WE, Tesar BM, Goldstein DR: Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol 2008;181:6747–6756.

45Gomez CR, Karavitis J, Palmer JL, Faunce DE, Ramirez L, Nomellini V, Kovacs EJ: Interleukin-6 contributes to age-related alteration of cytokine production by macrophages. Mediators Inflamm 2010;2010:475139.

46Puchta A, Naidoo A, Verschoor CP, Loukov D, Thevaranjan N, Mandur TS, Nguyen PS, Jordana M, Loeb M, Xing Z, Kobzik L, Larche MJ, Bowdish DM: TNF drives monocyte dysfunction with age and results in impaired anti-pneumococcal immunity. PLoS Pathog 2016;12:e1005368.

47Thome JJ, Yudanin N, Ohmura Y, Kubota M, Grinshpun B, Sathaliyawala T, Kato T, Lerner H, Shen Y, Farber DL: Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell 2014;159:814–828.

48Lavin Y, Winter D, Blecher-Gonen R, David E, Keren-Shaul H, Merad M, Jung S, Amit I: Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 2014;159:1312–1326.

49Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmid­leithner L, Ganesan H, Nino-Castro A, Mallmann MR, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T, Schultze JL: Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 2014;40:274–288.

50Conboy MJ, Conboy IM, Rando TA: Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell 2013;12:525–530.

51Li G, Smithey MJ, Rudd BD, Nikolich-Zugich J: Age-associated alterations in CD8alpha+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium. Aging Cell 2012;11:968–977.

52Becklund BR, Purton JF, Ramsey C, Favre S, Vogt TK, Martin CE, Spasova DS, Sarkisyan G, LeRoy E, Tan JT, Wahlus H, Bondi-Boyd B, Luther SA, Surh CD: The aged lymphoid tissue environment fails to support naive T cell homeostasis. Sci Rep 2016;6:30842.

53Snyder ME, Finlayson MO, Connors TJ, Dogra P, Senda T, Bush E, Carpenter D, Marboe C, Benvenuto L, Shah L, Robbins H, Hook JL, Sykes M, D’Ovidio F, Bacchetta M, Sonett JR, Lederer DJ, Arcasoy S, Sims PA, Farber DL: Generation and persistence of human tissue-resident memory T cells in lung transplantation. Sci Immunol 2019;4:eaav5581.

54Agius E, Lacy KE, Vukmanovic-Stejic M, Jagger AL, Papageorgiou AP, Hall S, Reed JR, Curnow SJ, Fuentes-Duculan J, Buckley CD, Salmon M, Taams LS, Krueger J, Greenwood J, Klein N, Rustin MH, Akbar AN: Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J Exp Med 2009;206:1929–1940.

55Vukmanovic-Stejic M, Chambers ES, Suarez-Farinas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE, Turner CT, Larbi A, Birault V, Noursadeghi M, Mabbott NA, Rustin MHA, Krueger JG, Akbar AN: Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation. J Allergy Clin Immunol 2018;142:844–856.

56Brubaker AL, Rendon JL, Ramirez L, Choudhry MA, Kovacs EJ: Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J Immunol 2013;190:1746–1757.

57Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD: Incidence and outcomes of acute lung injury. N Engl J Med 2005;353:1685–1693.

58Thompson WW, Shay DK, Weintraub E, Brammer L, Bridges CB, Cox NJ, Fukuda K: Influenza-associated hospitalizations in the United States. JAMA 2004;292:1333–1340.

59Cho SJ, Plataki M, Mitzel D, Lowry G, Rooney K, Stout-Delgado H: Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. Exp Gerontol 2018;105:40–46.

60Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS: The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation. Nat Immunol 2019;20:571–580.

61Frankel JH, Boe DM, Albright JM, O’Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ: Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes. Exp Gerontol 2018;105:78–86.

62Brandes M, Klauschen F, Kuchen S, Germain RN: A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection. Cell 2013;154:197–212.

63Mauad T, Hajjar LA, Callegari GD, da Silva LF, Schout D, Galas FR, Alves VA, Malheiros DM, Auler JO Jr, Ferreira AF, Borsato MR, Bezerra SM, Gutierrez PS, Caldini ET, Pasqualucci CA, Dolhnikoff M, Saldiva PH: Lung pathology in fatal novel human influenza A (H1N1) infection. Am J Respir Crit Care Med 2010;181:72–79.

64Shivshankar P, Boyd AR, Le Saux CJ, Yeh IT, Orihuela CJ: Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell 2011;10:798–806.

65Hinojosa CA, Mgbemena V, Van Roekel S, Austad SN, Miller RA, Bose S, Orihuela CJ: Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol 2012;47:958–965.

66Kling KM, Lopez-Rodriguez E, Pfarrer C, Muhlfeld C, Brandenberger C: Aging exacerbates acute lung injury-induced changes of the air-blood barrier, lung function, and inflammation in the mouse. Am J Physiol Lung Cell Mol Physiol 2017;312:L1–L12.

67Bajenoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN: Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends Immunol 2007;28:346–352.

68Luscieti P, Hubschmid T, Cottier H, Hess MW, Sobin LH: Human lymph node morphology as a function of age and site. J Clin Pathol 1980;33:454–461.

69Thompson HL, Smithey MJ, Uhrlaub JL, Jeftic I, Jergovic M, White SE, Currier N, Lang AM, Okoye A, Park B, Picker LJ, Surh CD, Nikolich-Zugich J: Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates. Aging Cell 2019;18:e12865.

70Richner JM, Gmyrek GB, Govero J, Tu Y, van der Windt GJ, Metcalf TU, Haddad EK, Textor J, Miller MJ, Diamond MS: Age-dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of West Nile virus infection. PLoS Pathog 2015;11:e1005027.

71Dixit VD: Thymic fatness and approaches to enhance thymopoietic fitness in aging. Curr Opin Immunol 2010;22:521–528.

72Mau T, Yung R: Adipose tissue inflammation in aging. Exp Gerontol 2018;105:27–31.

73Lumeng CN, Liu J, Geletka L, Delaney C, Delproposto J, Desai A, Oatmen K, Martinez-Santibanez G, Julius A, Garg S, Yung RL: Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J Immunol 2011;187:6208–6216.

74Frasca D, Diaz A, Romero M, Vazquez T, Blomberg BB: Obesity induces pro-inflammatory B cells and impairs B cell function in old mice. Mech Ageing Dev 2017;162:91–99.

75Carter S, Miard S, Caron A, Salle-Lefort S, St-Pierre P, Anhe FF, Lavoie-Charland E, Blais-Lecours P, Drolet MC, Lefebvre JS, Lacombe J, Deshaies Y, Couet J, Laplante M, Ferron M, Bosse Y, Marette A, Richard D, Marsolais D, Picard F: Loss of OcaB prevents age-induced fat accretion and insulin resistance by altering B-lymphocyte transition and promoting energy expenditure. Diabetes 2018;67:1285–1296.

76Youm YH, Grant RW, McCabe LR, Albarado DC, Ngu­yen KY, Ravussin A, Pistell P, Newman S, Carter R, Laque A, Munzberg H, Rosen CJ, Ingram DK, Salbaum JM, Dixit VD: Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab 2013;18:519–532.

77Youm YH, Kanneganti TD, Vandanmagsar B, Zhu X, Ravussin A, Adijiang A, Owen JS, Thomas MJ, Francis J, Parks JS, Dixit VD: The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep 2012;1:56–68.

78McBride MJ, Foley KP, D’Souza DM, Li YE, Lau TC, Hawke TJ, Schertzer JD: The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice. Am J Physiol Endocrinol Metab 2017;313:E222–E232.

79Stout-Delgado HW, Cho SJ, Chu SG, Mitzel DN, Villalba J, El-Chemaly S, Ryter SW, Choi AM, Rosas IO: Age-dependent susceptibility to pulmonary fibrosis is associated with NLRP3 inflammasome activation. Am J Respir Cell Mol Biol 2016;55:252–263.

80Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC: Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging (Albany, NY) 2015;7:38–52.

81Metcalf TU, Wilkinson PA, Cameron MJ, Ghneim K, Chiang C, Wertheimer AM, Hiscott JB, Nikolich-Zugich J, Haddad EK: Human monocyte subsets are transcriptionally and functionally altered in aging in response to pattern recognition receptor agonists. J Immunol 2017;199:1405–1417.

82HIPC-CHI Signatures Project Team; HIPC-I Consortium: Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses. Sci Immunol 2017;2:eaal4656.

83Beerman I, Bock C, Garrison BS, Smith ZD, Gu H, Meissner A, Rossi DJ: Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 2013;12:413–425.

84Lemke G, Rothlin CV: Immunobiology of the TAM receptors. Nat Rev Immunol 2008;8:327–336.

85Rothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S: TAM receptor signaling in immune homeostasis. Annu Rev Immunol 2015;33:355–391.

86Qin B, Wang J, Ma N, Yang M, Fu H, Liang Y, Huang F, Yang Z, Zhong R: The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjogren’s syndrome. Joint Bone Spine 2015;82:258–263.

87Zheng S, Hedl M, Abraham C: TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages. J Immunol 2015;194:1928–1937.

88Wang X, Malawista A, Qian F, Ramsey C, Allore HG, Montgomery RR: Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes. Oncotarget 2018;9:9572–9580.

89Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, Cohen PL, Earp HS, Matsushima GK: Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 2001;411:207–211.

90Seitz HM, Camenisch TD, Lemke G, Earp HS, Matsushima GK: Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol 2007;178:5635–5642.

91Wong CK, Smith CA, Sakamoto K, Kaminski N, Koff JL, Goldstein DR: Aging impairs alveolar macrophage phagocytosis and increases influenza-induced mortality in mice. J Immunol 2017;199:1060–1068.

92Cuervo AM, Wong E: Chaperone-mediated autophagy: roles in disease and aging. Cell Res 2014;24:92–104.

93Metcalf TU, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, Hiscott JB, Diamond MS, Wertheimer AM, Nikolich-Zugich J, Haddad EK: Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell 2015;14:421–432.

94Rizza W, Veronese N, Fontana L: What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Res Rev 2014;13:38–45.

95Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E: Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metab 2017;26:547–557 e548.

96Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA: A ketogenic diet extends longevity and healthspan in adult mice. Cell Metab 2017;26:539–546 e535.

97Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD: Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med 2017;9:eaai8700.

98Jiang W, Zhu Z, Thompson HJ: Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res 2008;68:5492–5499.

99Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM: mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 2010;468:1100–1104.

100Darcy J, McFadden S, Bartke A: Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations. Adipocyte 2017;6:69–75.

101Riera CE, Dillin A: Tipping the metabolic scales towards increased longevity in mammals. Nat Cell Biol 2015;17:196–203.

102Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D’Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD: The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 2015;21:263–269.

103Edwards C, Canfield J, Copes N, Rehan M, Lipps D, Bradshaw PC: D-beta-hydroxybutyrate extends life­span in C. elegans. Aging (Albany, NY) 2014;6:621–644.

104Pearce EL, Pearce EJ: Metabolic pathways in immune cell activation and quiescence. Immunity 2013;38:633–643.

105O’Neill LA, Pearce EJ: Immunometabolism governs dendritic cell and macrophage function. J Exp Med 2016;213:15–23.

106Camell C, Goldberg E, Dixit VD: Regulation of Nlrp3 inflammasome by dietary metabolites. Semin Immunol 2015;27:334–342.

107Serhan CN: Pro-resolving lipid mediators are leads for resolution physiology. Nature 2014;510:92–101.

108Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CN: Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. J Immunol 2014;193:4235–4244.

109Cai B, Kasikara C, Doran AC, Ramakrishnan R, Birge RB, Tabas I: MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity. Sci Signal 2018;11:eaar3721.

Ruth R. Montgomery, PhD

Department of Internal Medicine, Yale University School of Medicine

300 Cedar Street/TAC S413

New Haven, CT 06520-8031 (USA)

E-Mail ruth.montgomery@yale.edu