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One very interesting property of NK cells is their ability to modulate the functions of other innate and adaptive immune cells. Especially the NK cells interact with the DCs through crosstalk and cytokines [55]. Furthermore, it is well known from in vitro studies and colocalization experiments that NK cells can interact bidirectionally with DCs in areas of inflammation causing DC maturation, a consequent enhancement of NK cell function through positive feedback and exerting an influence on the polarization of primary T cell-responses toward a TH1 response [56–60]. In fact, mature DCs can activate NK cell cytotoxicity (NKCC) and IFNγ production, whereas activated NK cells are capable of enhancing DC maturation and IL-12 production. The previously described interactions are cell contact and TNFα-dependent [56, 61–63]. Furthermore, mature DCs recruit NK cells to the lymph nodes, by producing chemokines including the CXCR3 ligand CXCL9/MIG and substantial amounts of CXCL10/IP-10 and CXCL11/I-TAC where NK cells serve as an early source of the IFNγ necessary for Th1 polarization, possibly by direct interaction with naïve T cells [27]. Thus, this interaction would result in the activation of both cell types. Moreover, NK cells also influence B lymphocyte affinity maturation through the restriction of follicular helper T cells [64]. This is absolutely indispensable for the generation of broadly neutralizing antibodies. In this way, NK cells are largely participating in the efficacy of vaccination [14]. NK cells may also, via the production of IFNγ, participate in the activation of macrophages and T cells.