Читать книгу Vaccines for Older Adults: Current Practices and Future Opportunities - Группа авторов - Страница 23

For the numerous innate immune defects that develop with age, the impact of tissue milieu on innate immune cells may have particular relevance, but data from humans are limited, and additional novel approaches are desperately needed. Multiple mechanisms that cause cell-intrinsic defects have been identified in experiments using innate immune cells isolated from peripheral blood of elderly and adult donors. Notably, these mechanisms may occur simultaneously within particular cells, or across multiple populations, ultimately disarming the proper function of the aged innate immune system.