Читать книгу Vaccines for Older Adults: Current Practices and Future Opportunities - Группа авторов - Страница 30

The impact of chronic inflammation on innate immunity, both within immune cells and their tissue microenvironment, highlight a critical area for future investigation and potential novel therapeutic interventions. As we have described, multiple interconnected deficits arise during aging, both within innate immune cell subsets and the tissue milieu, to impair in vivo innate immunity in the elderly. With these complex layers of regulation, it remains challenging to fully define mechanisms of innate immune deficiencies. Collectively, these defects lead to poor priming of the adaptive immune system, culminating in poor immune protection and vaccination in the elderly. Given that in vitro stimulation of isolated circulating immune cells probably does not fully reflect their responsiveness within the tissue milieu, future studies will require appropriate in situ tissue studies and animal models. Along with development of new approaches to define age-related defects in innate immunity, a critical priority is novel therapeutic interventions targeting systemic inflammation to address immune dysfunction and enhance healthy life-span.