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In addition to metabolic programming, dietary metabolites can have important cell signaling functions. While we have focused on innate immune activation defects that contribute to increased infection susceptibility in the elderly, an equally important aspect of the innate immune system is the resolution of inflammation. Key to resolution is a family of pro-resolution bioactive lipid mediators synthesized from omega-3 fatty acids, namely docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) – the resolvins, lipoxins, and maresins [107]. Aged mice exhibit delayed bacterial clearance and have reduced levels of these pro-resolving lipid metabolites [108]. Innate immune cells are capable of metabolizing DHA and EPA to generate these metabolites, and this improves efferocytosis in human monocytes [108]. Finally, MerTK-dependent ERK activation induces pro-resolving lipoxin LXA₄ production in human monocyte-derived macrophages [109]. Perhaps age-related changes in tissue milieu can be restored by improving inflammation resolution in the elderly. Future investigations in this domain are warranted to explore their potential for dampening chronic inflammation during aging to improve innate immunity.