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NK cells are innate lymphoid cells which play a major role in the defense of the organism against viral infections and malignancies and comprise around 10–20% of the total peripheral lymphocyte population [17–19]. They are able to kill cells presenting abnormal MHC signatures either because of intracellular (viral) infection or because of neoplastic transformation [20–22]. Moreover, very recently other functions of NK cells have been described, including a wider polyfunctional antimicrobial response, elimination of senescent cells, resolution of inflammation, and induction of adaptive immune responses [23–28]. This is occurring constitutively; however, they may also present some characteristics of the adaptive response [29, 30]. NK cells consist of a relatively wide range of subpopulations characterized by their surface markers including various receptors [31, 32].