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The PSC recommends a repeat FNA procedure when the first attempt yields a non-diagnostic cytology sample. The clinical team may elect to proceed to laparotomy without repetition depending on the radiographic and clinical findings for obtaining a Tru-Cut needle biopsy. If the first attempt was via brushings, it can be repeated by brushings or EUS-FNA. If the first attempt was by percutaneous FNA then it may be most reasonable to use EUS-FNA for the second attempt. If the first attempt was EUS-FNA, reassessment of the EUS findings and other imaging should be undertaken, followed by a review of the FNA line of approach [30]. Repeat aspiration of a cystic lesion of the pancreas should be carefully considered due to there being up to 14% risk of associated infection.