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A negative cytology may indicate benign entities like acute, chronic, and autoimmune pancreatitis, pseudocyst, ectopic and intrapancreatic splenule, and lymphoepithelial cyst. If cytopathology is diagnostic of a specific benign entity, then the treatment is aimed to treat that particular entity. However, if the negative cytology diagnosis is descriptive without a specific benign entity diagnosis, it should not be taken to be synonymous with a benign lesion. The multidisciplinary team should evaluate the clinical presentation, radiographic findings, and cytopathology, and should reassess the component that is discrepant. False negative interpretations are not uncommon in pancreatic EUS-FNA due to sampling and interpretive errors. If the lesion is clinically suspicious, FNA may be repeated to collect diagnostic material.