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Glycogenic acanthosis

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Glycogenic acanthosis is a benign condition in which there is accumulation of cytoplasmic glycogen in the squamous epithelial cells lining the esophagus, causing focal, plaque‐like thickening of the mucosa [116, 117]. It is a benign, degenerative condition, occurring primarily in elderly individuals. Glycogenic acanthosis can often be recognized on double‐contrast studies by the presence of multiple small, rounded nodules or plaques in the mid or, less commonly, distal esophagus [118] (Figure 6.59). The major consideration in the differential diagnosis is Candida esophagitis. However, the plaques of candidiasis tend to have a more linear configuration and typically occur in immunocompromised patients with odynophagia, whereas glycogenic acanthosis typically occurs in older individuals who are not immunocompromised and have no esophageal symptoms. Thus, it is usually possible to differentiate these conditions on the basis of the clinical and radiographic findings.


Figure 6.48 Herpes esophagitis in an otherwise healthy patient. Double‐contrast view shows innumerable punctate ulcers clustered together in the mid esophagus below the level of the left main bronchus.

Source: Reproduced from DeGaeta L, Levine MS, Guglielmi GE, et al. Herpes esophagitis in an otherwise healthy patient. AJR Am J Roentgenol1985; 244:1205–1206, with permission.

The Esophagus

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