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Before going into the new technology and science in detail, it is important to recognize that this lab evolution will be driven not just by new technologies and new science. In our view, there are four additional broader, yet fundamental and complementary attributes that influence how a lab environment changes over time. They are:

1 People and culture considerations

2 Process developments and optimization

3 Data management improvements

4 Lab environment and design

When we add the fifth major driver of change – new technology (including new science) – it becomes clear that digital transformation is a complex, multivariate concept (Figure 1.1).

Figure 1.1 Complex, multivariate concept of lab transformation.

In this section, we discuss how each of these high‐level attributes will influence the changing lab and the expectations of the users. For all five areas, we include what we think are some of the most important aspects, which we believe will have the most impact on the “LotF.”