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The lab environment, its design, usability, and sustainability are mentioned previously in this section and elsewhere in the book, but it is fair to say that all labs will face the pressure [17, 18] to design sustainable spaces [19] that can keep up with all the emerging technical trends as well as the usability and design features needed to support a new generation of scientists. These drivers will combine to influence how the LotF evolves and experiments are performed. Research institutions are already creating more “open” labs areas to support interdisciplinary teamwork, collaborative working, and joint problem solving, rather than the previous “siloed” departmental culture. This will continue in the LotF. The growth of innovation clusters [20] and lab coworking spaces will require more consideration as to how shared automation and lab equipment can be effectively and securely used by groups, who may be working for different organizations and who will want to ensure their data and methods are stored and protected in the correct locations. Effective scheduling will be critical in the LotF to enable high productivity and to ensure that the high value of the automation assets is realized.