Читать книгу Assisted Reproduction Techniques - Группа авторов - Страница 163

Vishvanath C. Karande

Department of Reproductive Endocrinology and Infertility, InVia Fertility Specialists, Hoffman Estates, Illinois, USA

Case History: A 26‐year‐old woman presented with a history of premature ovarian failure secondary to radiation and chemotherapy for the treatment of Hodgkin’s lymphoma at age 18. Her follicle stimulating hormone level was 85mIU/mL and anti‐Müllerian hormone level was <0.1 ng/mL. Ultrasound evaluation showed the ovaries to be small (1.5 mL in volume each) with no antral follicles. The uterus had a volume of 40 mL and thin endometrial lining at 4 mm. She was accepted to our donor oocyte program. Prior to the transfer cycle, she was treated sequentially with physiologic doses of estradiol (Estrace, 4 mg) orally and vaginal progesterone (Crinone gel, 8%) for 3 months. This resulted in a slight increase in the uterine volume (45 mL) and a peak endometrial thickness of 9 mm. There was a clinical pregnancy which unfortunately resulted in a spontaneous miscarriage at 8 weeks’ gestation.