Читать книгу Assisted Reproduction Techniques - Группа авторов - Страница 175

Nivedita Reddy

Assisted Conception Unit, Guy’s Hospital, London, UK

Case History 1: A 35‐year‐old woman presented with inability to conceive for 1 year. She had breast cancer diagnosed at the age of 28 and was treated with surgery followed by six cycles of chemotherapy and concomitant GnRH analogue, followed by tamoxifen for 5 years. Her menstrual cycles had been irregular but were now regular. She was seen prior to commencing chemotherapy when she had oocyte retrieval and embryos cryopreserved for fertility preservation.

Case History 2: A 31‐year‐old single woman presented with a history of one‐year subfertility and irregular menstrual cycles. She had a history of Hodgkin’s Lymphoma (HL) stage 2 at the age of 20, treated with three cycles of ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine), GnRH analogue and local radiotherapy to the chest. As the desired response was not achieved, the treatment was escalated to BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). The anti‐Müllerian hormone (AMH) level was 12.3 pmol/L at diagnosis. She was offered oocyte freezing for fertility preservation prior to chemotherapy but declined it in order to avoid delay in commencing treatment. Concomitant GnRH analogues were administered during her chemotherapy.