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Ethical considerations

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There are two main ethical issues involved in both case histories. The first relates to the morality of terminating a pregnancy affected with cystic fibrosis when the disease expression is variable and could range from very mild to severe, and advances in medical management of the disease have progressed to the stage where living a relatively fulfilling life until the fourth decade of life is commonplace. The second issue is the notion of replacing cystic fibrosis carrier embryos after PGT. In view of the complete lack of symptoms in cystic fibrosis carriers, discarding a cystic fibrosis carrier embryo at the time of PGT may be considered by some tantamount to eugenics. These are challenging situations and difficult decisions, and affected couples should be fully counseled and appropriately supported.

Assisted Reproduction Techniques

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