Читать книгу Assisted Reproduction Techniques - Группа авторов - Страница 69

Challenge: Conventional and herbal drugs in patients undergoing ART.

Background:

 Patients undergoing ART and pregnant women commonly take prescribed and/or over‐the‐counter medicinal products.

 Drugs, whether medical or herbal, may have harmful effects on a pregnancy, ranging from miscarriage to developmental anomalies and fetal growth restriction.

Management:

 Regularly reassess the need for medication in women trying to conceive or who become pregnant, and where possible consider nonpharmacological interventions.

 Avoid drugs in the first trimester if possible.

 Prescribe if the expected benefit outweighs the risks.

 Prescribe drugs that have long been used in pregnancy with a good safety record over new or untested drugs.

 Use the smallest effective dose for the shortest period of necessity.

 Consult a pharmacist or teratology information service when in doubt about a drug’s most up‐to‐date safety profile in pregnancy.

 Always involve women in decisions made about pharmacological interventions in pregnancy.

Additional information:

 BNF (www.medicinescomplete.com)

 UK Teratology Information Service (www.uktis.org)

 TOXBASE (www.toxbase.org)

 MotherToBaby (www.mothertobaby.org)

 Drugs in Pregnancy and Lactation, 11th ed. G.G. Briggs, R.K. Freeman, C.V. Towers, A.B. Forinash

 Micromedex (www.micromedexsolutions.com)