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 Vascular thrombosis: one or more clinical episodes of arterial, venous or small vessel thrombosis, in any tissue or organ. Thrombosis must be confirmed by objective validated criteria (i.e. unequivocal findings of appropriate imaging studies or histopathology). For histopathologic confirmation, thrombosis should be present without significant evidence of inflammation in the vessel wall.

 Pregnancy morbidity:

 one or more unexplained deaths of a morphologically normal fetus at or beyond 10 weeks’ gestation, with normal fetal morphology documented by ultrasound or by direct examination of the fetus; or

 one or more premature births of a morphologically normal neonate before 34 weeks’ gestation because of: (i) eclampsia or severe preeclampsia defined according to standard definitions; or (ii) recognized features of placental insufficiency; or

 three or more unexplained consecutive spontaneous abortions before 10 weeks’ gestation, with maternal anatomic or hormonal abnormalities and paternal and maternal chromosomal causes excluded.