Читать книгу Sarcopenia - Группа авторов - Страница 33

In spite of some inconsistencies in the literature, there is enough evidence to conclude that mitochondrial volume and function in skeletal muscle decline with aging. However, there is substantial disagreement on possible causal mechanisms that lead to such decline. Here, we review briefly the main theories and mention some of the supportive evidence.

It is important to recognize that most of the available evidence is based on studies conducted on animal models or human studies with a cross‐sectional design, and substantial work still needs to be conducted to better identify the molecular changes that are associated with the decline of muscle mitochondrial health with aging.