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Most of the studies failed to show any beneficial effect of nutritional supplementations on muscle anabolic properties in exercising older persons. For example, Welle et al. reported that high‐protein meals (0.6–2.4 g protein/kg/d) did not enhance the myofibrillar protein synthesis rate in vastus lateralis muscle following three sessions of resistance exercise in 62‐ to 75‐year‐old men and women [99]. In very old frail people (87 years old), high‐intensity resistance exercise training with or without concomitant multinutrient supplementation had the same efficiency on muscle weakness reversibility [99]. Of note, reports showed that ingestion of oral pre‐ or post‐exercise amino acid supplements can improve net muscle protein balance in young subjects [100, 101]. The response to amino acid intake with concomitant exercise is dependent upon the composition and amount, as well as the pattern and timing of amino acid ingestion in relation to the performance of exercise [102]. The response of net muscle protein synthesis to consumption of an EAA–carbohydrate supplement solution immediately before resistance exercise is greater than when the solution is consumed after exercise, primarily because of an increase in muscle protein synthesis as a result of increased delivery of amino acids to the leg [103]. Whether amino acid and carbohydrate intakes immediately before or after resistance exercise can enhance the anabolic effect of training in older individuals as shown in the younger group is still controversial. It was shown that dietary protein digestion and absorption kinetics were not impaired after exercise at an older age. Moreover, exercising before protein intake allows for a greater use of dietary protein‐derived amino acids for de novo muscle protein synthesis in both young and older men, likely contributing to improve muscle function [98]. We investigated changes in muscle strength and fatigue of 60‐year‐old men following a 16‐week multicomponent exercise training program combined with whey proteins or total milk proteins supplementation [73]. We observed significant increases in muscle mass and strength and a reduction in muscle fatigue following training coupled with the daily consumption of 10 g of whey proteins, as compared with total milk proteins, in these subjects. Obviously, it is most important to optimize the anabolic response to resistance exercise in these participants with the aim of preserving muscle mass and function. As people are considered to prefer well‐known nutrient products that are accessible and palatable, the recommendation of exercise‐timed soluble milk protein consumption appears to be especially well suited to older individuals involved in training programs.