Читать книгу Clinical Dilemmas in Diabetes - Группа авторов - Страница 23

Although neural dysfunction is associated with hyperglycemia, clinicians should be mindful that neurologic deficits can be attributable to non‐glycemic causes in individuals with prediabetes and DM [62]. Subjects with isolated IGT were shown to have subclinical neural dysfunction that was generally asymptomatic and characterized by small‐fiber neuropathy and mild impairment of cardiovascular autonomic function [63]. Erectile dysfunction has also been shown to be independently associated with IFG, with an odds ratio of 1.26 (95% confidence interval 1.08–1.46) [64]. Prediabetic‐range hyperglycemia is also associated with chronic idiopathic axonal polyneuropathy (CIAP) [65]. In a study of 100 subjects with CIAP, 36 individuals were found to have IFG, 3 had FPG ≥ 126 mg/dL, 38 had IGT, and 24 had 2‐h PG ≥ 200 mg/dL. Overall, the prevalence of dysglycemia in this cohort was approximately 2‐fold higher than in an age‐matched general population group.