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Key Points

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 Presentation of a neck mass in an adult should be considered cancer until proven otherwise. All patients should have a thorough assessment of the upper aerodigestive tract at the time of the initial office evaluation.

 PET/CT is the best imaging modality for thorough assessment of the neck and upper aerodigestive tract when assessing a patient with an unknown primary carcinoma.

 Viruses are an etiologic factor in head and neck carcinoma, and testing for HPV and EBV can be performed on the FNA specimen to yield valuable additional information.

 Patients with a single lymph node and without evidence of extranodal extension of disease may be successfully treated with a surgical approach involving complete resection of the primary and neck dissection if there is no perineural or lymphovascular invasion and if the primary site is small and has negative margins.

 Lingual tonsillectomy and palatine tonsillectomy should be performed in cases of an unknown primary as the tonsils are often the site of unknown primary tumors.

Essential Cases in Head and Neck Oncology

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