Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 154

Several studies have documented that brain ageing is associated with an increase in the amount of damaged nuclear and mitochondrial DNA and a concomitant reduced expression and activity of some DNA repair proteins. In aged neurons, DNA is thereby more prone to accumulating oxidative damage with important implications in terms of gene expression, synaptic plasticity, and mitochondrial function.^23,37