Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 376

Human ageing tends to be associated with increased fasting and postprandial circulating insulin concentrations.⁵⁹ Increased insulin activity could, therefore, be a cause of reduced food intake in older people. However, the evidence for a satiating role of insulin is limited. Suppression of food intake by insulin has only been demonstrated in animals and has required central insulin administration at high doses or high‐dose, prolonged peripheral administration. Short‐term, peripheral, euglycaemic insulin infusions have been shown not to affect appetite or food intake in humans.⁶⁰ Moreover, age‐associated increases in insulin concentrations are due mainly to insulin resistance resulting from increased adiposity and only to a small extent to ageing itself. It seems unlikely that insulin contributes substantially, if at all, to the anorexia of ageing.