Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 510

Constipation has long been misunderstood as a common problem associated with ageing. The prevalence of self‐reported constipation, physician visits, and laxative use increase with ageing.^3‐5 In contrast, reported stool frequency does not change with age.^3,4 Challenges in defining the prevalence of constipation in elders relates to the variety of criteria used in different studies. Self‐reported constipation affects 27% of individuals age 65 and older, whereas only 17% of elders meet more stringent (e.g. Rome criteria) diagnostic criteria for chronic constipation.⁶ When adjusting for race and laxative use, odds ratios for fewer than three bowel movements per week in individuals age 70–79 and ≥80 were 0.61 (95% confidence interval [CI], 0.51–0.72) and 0.85 (95% CI, 0.68–1.03), respectively, compared with individuals <40 years of age.³ Thus, age alone is not an independent risk factor for reduced stool frequency. Likewise, little evidence exists to support low‐fibre diets, lack of fluid, or reduced exercise as contributing to constipation in the otherwise healthy older patient.^7,8 Elderly women are two to three times more likely to report constipation than their male counterparts.⁹ Non‐whites and individuals of lower socioeconomic status report fewer stools.¹⁰ In community‐dwelling frail elders, up to 45% report constipation as a health concern.¹¹ The prevalence is higher in nursing home residents, with 74% of people symptomatic of constipation and requiring laxatives.¹² In older people, the development of constipation is often multifactorial and typically represents the effects of medications, reduced dietary fibre intake, immobility, and comorbid diseases.¹³ The traditional perception of constipation due to ageing no longer holds; the healthy older person is not predestined to develop constipation.

Elders reporting constipation more often describe straining and hard bowel movements than reduced stool frequency.^3,14,15 Population‐based prevalence of constipation includes 40% of community‐dwelling adults over the age of 64.¹⁶ The presence of constipation is also associated with medication use, including beta blockers, calcium channel blockers, anticholinergic drugs, and opiates.¹⁷ Despite the lack of difference in risk factor–adjusted constipation rates between elders and younger individuals, elders more frequently use laxatives. Up to 50% of elderly women report the use of laxatives. Overall, 20–30% of community‐dwelling elders use laxatives on at least a weekly basis. In the United States, a systematic review of the economic burden of IBS and chronic constipation showed that per patient, between $1912 to $7522 per year was spent on medications, hospitalization, outpatient clinics, emergency visits, and laboratory tests.¹⁸ Most elders self‐treat with over‐the‐counter products; hence the economic impact of laxative use is probably considerably higher than this estimate.

The findings of similar stool frequency but increased defecatory difficulty parallel the reported physiological changes that occur in the digestive tract with ageing. Colon transit overall is generally well preserved with ageing in humans.¹⁹ Changes in pelvic floor function may contribute to defecatory difficulty, with older women demonstrating reduced opening of the anorectal angle and a greater degree of perineal descent compared with younger women.²⁰ Pudendal neuropathy also occurs more commonly with ageing and may negatively affect pelvic floor function.²¹ Other factors correlated with constipation in ageing include reduced caloric intake, use of multiple medications, haemorrhoids, and pain in the abdomen.^22,23 Many diseases that occur more commonly in elders also contribute to the development of constipation, such as diabetes mellitus, Parkinson’s disease, and stroke. Prior surgery may also affect bowel function in elders. In women over 50 years of age, hysterectomy results in prolonged colon transit time and greater complaints of constipation and straining than in controls.²⁴ Since ageing alone has little influence on the development of constipation, when complaints of constipation occur in elders, it commonly relates to medical comorbidities and increased defecatory difficulty.

Constipation is a frequently reported bowel symptom in the elderly, with a considerable impact on quality of life and health expenses. The consequences of constipation in elders make it a significant health problem. Chronic constipation impacts functioning in daily living, and elders with these complaints rate their health lower than people without gastrointestinal symptoms.²⁵ These findings were not confounded by the presence of other chronic illnesses or medication use. Health‐related quality of life is reduced in patients with chronic constipation.²⁶ The presence of constipation has also been hypothesized to increase urinary tract symptoms, with the treatment of constipation resulting in reduced urinary frequency, urgency, and dysuria.²⁷ Increased weekly bowel movements due to laxative use also led to patients reporting better sexual function and improved mood and depression.¹²

Constipation is also associated with bowel incontinence, and treatment of constipation reduces incontinence episodes.^28,29 Faecal impaction is a common problem in the elderly; it is estimated that 7% of institutionalized elderly have impacted faeces on rectal examination.³⁰ The first indication of impaction may be overflow diarrhoea and rectal incontinence; if a rectal examination is not performed, there is a risk of impaction being misdiagnosed and treated with antidiarrheal agents.³¹ Immobile or cognitively impaired individuals with constipation face an increased risk of faecal impaction, stercoral ulceration, and colon perforation.^28,32 Constipation reduces quality of life and diminishes self‐perceived health in community‐dwelling elders.²⁵ More effective strategies are needed for reducing the burden of illness and costs associated with constipation.