Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 521

Tegaserod is a selective partial serotonin (5‐HT4) receptor agonist that promotes gut motility and improves constipation symptoms but since 2007 is not recommended in the elderly due to an increase in cardiovascular ischaemic events.⁵⁷ Prucalopride, a 5‐HT4 receptor antagonist, has been shown to treat chronic constipation by increasing colonic motility and transit. Trials have shown prucalopride can improve symptoms in severe chronic constipation over six months of symptoms despite treatment with at least two different classes of laxatives.⁵⁷ Prucalopride was considered safe in the elderly with minimal cardiovascular‐related adverse events, but recent studies found it is associated with cardiac arrhythmias.