Читать книгу Veterinary Surgical Oncology - Группа авторов - Страница 151

FSAs are tumors derived from mesenchymal cells or fibroblasts. FSAs infiltrate surrounding tissues, are locally aggressive, and metastasize hematogenously to distant sites including the lungs, liver, bone, brain, and skin (Powers et al. 1995). Tumor grade is an important determinant in the histologic assessment of soft tissue‐origin FSA. Grade I or II FSAs of the skin are unlikely to metastasize. Aggressive and complete surgical excision is the treatment of choice for these FSAs, and long‐term control or cure is likely with aggressive surgery with or without radiation therapy. A grade III, or high‐grade, FSA is more likely to metastasize, and adjuvant chemotherapy is warranted (Dernell et al. 1998; Davis et al. 2007). Radiation therapy or chemotherapy may also be indicated in the case of unresectable FSA. For microscopic local residual disease, radiation therapy seems to be an effective treatment option (Chun 2005; Forrest et al. 2000; Little and Goldschmidt 2007; Mikaelian and Gross 2002). In contrast to FSAs of the skin, FSAs originating from the oral cavity generally behave in a more malignant way and carry a poorer prognosis due to an invasive growth pattern (Ciekot et al. 1994).