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Since the demonstration of the ability of CRISPR/Cas systems to precisely and efficiently edit gene sequences in 2012, CRISPR has become embedded as a routine technique in molecular and cell biology laboratories across the field. New industries have been created to supply CRISPR reagents and CRISPR‐edited cell and animal models to the research scientist, to develop CRISPR medicines and to create CRISPR diagnostics. The applications and impact of CRISPR in drug discovery are discussed at length within this book. Within eight short years, CRISPR has transformed our ability to identify and characterize the role of new drug targets in disease and to create the cell and animal models integral to identify and optimize drug candidates. With the rate of innovation in this field, we can look forward to the development of novel CRISPR systems that increase the efficiency and specificity of gene editing, to the development of transformative CRISPR therapies with the potential to cure severe genetic diseases and to the invention of highly sensitive diagnostics for the early identification and subsequent cure of many common diseases. As we move through the coming decades, the opportunity for CRISPR to improve human health remains enormous.