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In this chapter, we reviewed important design considerations for CRISPR experiments and the major providers of reagents, and discussed ways of working with CROs for genome editing projects. Many of the considerations are equally applicable to projects carried out in‐house. Regardless of where the genome editing projects are to be conducted, we suggest applying the formula Model x Assay x Perturbation, as well as the triple constraint principle – quality, time, and cost – in designing and managing execution of each project. We hope that the guidelines discussed here will help researchers strike an appropriate balance of these principles to maximize scientific impact of this exciting technology within a given budget or resource.