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OCT3 is regulated by various transcription factors including specificity protein 1 (Sp1), myeloid zinc finger 1 (MZ1), p300, and Ap4. These transcription factors bind to DNA response elements in the basal promoter of OCT3 [2]. In addition, methylation of the basal promoter of OCT3, which is tissue specific, suggests that regulation of the transporter is epigenetic in some tissues. In addition, Sp1 and USF1 bind to response elements in the upstream promoter, modulating the expression of OCT3 [2].