Читать книгу Drug Transporters - Группа авторов - Страница 52

Within the human SLC22 transporter family, the zwitterion transporter subfamily is composed of hOCTN1 (SLC22A4), hOCTN2 (SLC22A5), FLIPT1/SLC22A15 (SLC22A15), and CT2 (SLC22A16), among others. These transporters play important physiological and pharmacological roles, acting in the influx and efflux of essential endogenous compounds (e.g., carnitine and ergothioneine), drugs, and various xenobiotics. Alterations in the expression and function of these transporters can lead to various pathophysiological conditions.