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The term computer‐aided/assisted design is usually abbreviated as CAD. The methods used for image acquisition (CBCT, scanning imaging, photographs) and manipulation (software programs) can be included in CAD. On the other hand, computer‐aided/assisted manufacturing (CAM) includes processes such as 3D printers (additive manufacturing) and milling devices (subtractive manufacturing). CAD‐CAM technologies are currently used in biomedical engineering, clinical medicine, customized medical implants, tissue engineering, dentistry, artificial joint manufacture, and robotic surgery. Furthermore, the use of CAD‐CAM technologies has been increasing in various fields of study of medicine and dentistry [5, 6]. Among the main devices that can be digitally designed and manufactured are different types of dental restorations and prostheses, surgical guides, occlusal splints, dental casts, and orthodontic aligners [5, 7]. Details of the main clinical applications of CAD‐CAM in dentistry are further addressed in the next chapters.