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The urogenital microbiome interacts with various aerobic and anaerobic microorganisms with the host, including microbes from the bladder [35, 36] and reproductive tract [37]. The microbiota bladder and urinary tract include aerobic bacteria such as E. coli and Enterococcus faecalis [38], and anaerobic bacteria such as Corynebacterium, Lactobacillus, and Ureaplasma [39–41]. The vaginal microbiota comprises mainly Lactobacillus spp. and Bifidobacterium [42] that prevent pathogenic infections by acidifying the lower genital tract. Patients suffering from interstitial cystitis showed lower bacterial diversity with enriched populations of Lactobacillus (92% of the total microbial population) compared to the abundance in healthy individuals (57% of the total microbial population) [35]. The changes in urogenital microbiota were found to be linked to other medical ailments and chronic inflammatory diseases such as inflammatory bowel disease (IBD) [43], suggesting a link between the urogenital microbiome and the digestive tract. Therefore, the study of the urogenital microbiome can be used as a good indicator to determine the host health by using patient urine samples.