Читать книгу Catalytic Asymmetric Synthesis - Группа авторов - Страница 95

The developments in the field of chiral cation phase‐transfer and ion‐pairing catalyses have displayed immense advancements for the field of catalysis. Despite the long history of this mode of catalysis, the charged‐reversed version, chiral‐anion catalysis, has been a significantly more recent development. This mode of activation centers on utilizing chiral‐anions to impart enantioselectivity on cationic intermediates and reagents via ion‐pairing. One advantage of this strategy is the orthogonal reactivity that can be achieved by focusing on transformations that feature cationic intermediates from relatively unactivated starting materials under mild conditions.

Scheme 4.30. Asymmetric Strecker reaction catalyzed by BINOL‐derived crown ether.

Source: Based on [99].