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Papers of Special Interest

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Ellis EL, Delbrück M. 1939. The growth of bacteriophage. J Gen Physiol 22:365–384.

A landmark paper describing the development of the plaque assay to measure infectivity of bacteriophage and its use in studying viral reproduction by one-step analysis.

Reed LJ, Muench H. 1938. A simple method for estimating fifty percent endpoints. Am J Hyg 27:493–497.

An important paper that shows how to estimate 50% endpoints in titrations of viruses in animals.

Guo F, Li S, Caglar MU, Mao Z, Liu W, Woodman A, Arnold JJ, Wilke CO, Huang TJ, Cameron CE. 2017. Single-cell virology: on-chip investigation of viral infection dynamics. Cell Rep 21:1692–1704.

A seminal paper that presents a pneumatic device for measuring infection of single cells with poliovirus and its use to measure the heterogeneity of infection.

Principles of Virology

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