Читать книгу Principles of Virology - Jane Flint, S. Jane Flint - Страница 154

A mutation is a change in DNA or RNA comprising base changes and nucleotide additions, deletions, and rearrangements. When mutations occur in open reading frames, they can be manifested as changes in the synthesized proteins. For example, one or more base changes in a specific codon may produce a single amino acid substitution, a truncated protein, or no protein. The terms “mutation” and “deletion” are often used incorrectly or ambiguously to describe alterations in proteins. In this textbook, these terms are used to describe genetic changes and the terms “amino acid substitution” and “truncation” to describe protein alterations.