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Three-Dimensional Structures of RNA-Dependent RNA Polymerases

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Viral RdRPs show the highest degree of conservation of all viral proteins and are the only proteins common to all RNA viruses. Seven conserved sequence motifs (A to G) that contain amino acid residues crucial for enzymatic function have been identified in all RdRPs (Fig. 6.4). Some of the conserved sequence motifs are shared among all four classes of nucleic acid polymerases (Fig. 6.4).

Principles of Virology

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