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Capping

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Most viral mRNAs carry a 5′-terminal cap structure (exceptions include picornaviruses and the flavivirus hepatitis C virus), but the modification is made in different ways. Three mechanisms can be distinguished: acquisition of preformed 5′ cap structures from cellular pre-mRNAs or mRNAs as described above, de novo synthesis by cellular enzymes, or synthesis by viral enzymes. Details of the latter processes can be found in Chapter 8.

Principles of Virology

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